Naegleria fowleri : emerging therapies and translational challenges

Effective management of N. fowleri infections hinges on early detection and addressing research gaps, particularly in understanding transmission/disease mechanisms. Recent advances in therapeutics, diagnostics, and water treatment to reduce environmental contamination by N. fowleri show promise for lowering infection risk and improving outcomes for primary amebic meningoencephalitis. Collaboration among academic institutions, pharmaceutical companies, and water industries is essential, with research advancing treatments and vaccines, and water industries contributing by reducing environmental contamination/human exposure to N. fowleri. A combination of treatment strategies and stringent surveillance will be crucial to limit future outbreaks and improve patient prognosis.