化学
催化作用
烷基
镍
电泳剂
酒
试剂
偶联反应
有机化学
组合化学
药物化学
作者
Patricia C. Lin,Chloe D. Wong,Elizabeth R. Jarvo
标识
DOI:10.1002/anie.202403119
摘要
Nickel‐catalyzed cross‐electrophile coupling reactions of two aliphatic alcohol derivatives remain a challenge. Herein, we report a nickel‐catalyzed reductive methylation reaction of aliphatic mesylates with methyl tosylate. This reaction provides straightforward access to compounds bearing aliphatic methyl groups from alkyl alcohol derivatives. Isotopically labelled substrates and reagents can be employed in the reaction to provide perdeuterated and 13C‐labelled products. This transformation can be achieved by employing stoichiometric Mn reductant or electrochemically. Additionally, mechanistic experiments show that alkyl iodides are key intermediates in the transformation which undergo a stereoablative reaction via radical intermediates.
科研通智能强力驱动
Strongly Powered by AbleSci AI