Prospective roles of sirtuin 1 (SIRT1) in oral cancer therapy

• SIRT1 is a promising target in oral cancer as it regulates proliferation, apoptosis, and DNA repair. • SIRT1 acts as a tumor suppressor, and low SIRT1 levels have been linked to lymphovascular permeation. • SIRT1 is involved in the regulation of the epithelial-mesenchymal transition, a process critical for cancer metastasis. • SIRT1 regulates various signaling pathways implicated in oral cancer progression, including PI3K/Akt, MAPK, and NF-κB pathways.