牙周炎
医学
三叉神经节
牙周组织
炎症
TRPV1型
睡眠剥夺
内科学
免疫学
内分泌学
神经科学
受体
生物
昼夜节律
牙科
瞬时受体电位通道
感觉系统
作者
J. Li,Zhizhong Cui,Hongyu Gong,Yan Zhang,Zhiyong Yuan,Zi-Hao Zhang,Zengyi Ma,Nan Zhou,Chuanxin Huang,Yao Zhao,Xia Li,Zhi Zhang,Yao Sun
标识
DOI:10.1073/pnas.2424169122
摘要
Periodontitis, a prevalent chronic inflammatory disease, profoundly impacts both quality of life and overall health. Clinical studies have suggested a correlation between periodontitis and sleep deficiency, but the underlying mechanisms involved remain elusive. Here, we observed an elevated risk of periodontitis in individuals with sleep deficiency, as demonstrated in both clinical subjects and mouse models. Retrograde tracing from the periodontium revealed a neural connection from trigeminal TRPV1 neurons, which may mediate the aggravating effects of sleep deficiency on periodontitis. The ablation of TRPV1 neurons effectively mitigated the aggravating effects of sleep deficiency on periodontitis. Under periodontitis, sleep restriction increased the secretion of substance P from trigeminal neurons in the periodontium, enhancing vasodilation and vascular permeability, which in turn promoted the infiltration of proinflammatory immune cells. Blocking substance P signaling via a Neurokinin-1 receptor antagonist or knocking down Tacr1 in vascular endothelial cells alleviated these detrimental effects. Our findings unveil a critical neuron-vessel-immune axis that exacerbates periodontitis during sleep deficiency and suggest potential therapeutic strategies targeting this axis for managing periodontitis in individuals suffering from sleep deficiency.
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