姜黄素
氧化应激
KEAP1型
TFEB
炎症
药理学
支气管肺泡灌洗
化学
自噬
砷
蛋白激酶B
砷毒性
肺
转录因子
免疫学
生物
生物化学
信号转导
医学
内科学
细胞凋亡
有机化学
基因
作者
Guang Xu,Haiyang Chen,Cong Zhou,Rui-Qiang Wang,Xiangping Li,Yun Xie,Yi Wang,Bing Li
标识
DOI:10.1016/j.jnutbio.2023.109550
摘要
Arsenic is a human carcinogen widely distributed in the environment, and arsenic exposure from drinking water has received widespread attention as a global public health problem. Curcumin is a natural bioactive substance with high efficiency and low toxicity extracted from turmeric, which has a variety of biological properties such as anti-oxidation, anti-inflammation, anti-cancer, and immuno-modulatory activities. Curcumin is widely used in daily life as a food additive and dietary supplement. However, its protective effects in lung injuries by chronic arsenic exposure orally remain unexplored. In this study, curcumin treatment not only significantly accelerated arsenic elimination and improved lung tissue morphology, but also decreased arsenic-generated ROS by activating Nrf2 and its down-stream antioxidants. Further, curcumin alleviated inflammatory changes in mice exposed to arsenic for 6 and 12 weeks, as manifested by lung MPO levels, total protein and cellular levels in bronchoalveolar lavage fluid (BALF), serum IL-4 levels, and MAPK/NF-κB expression in lung tissue. Notably, our study also confirmed that curcumin could promote the expression and nuclear translocation of the transcription factor EB (TFEB), as well as activate TFEB-regulated autophagy in lung tissue of arsenic-treated mice, accompanied by inhibition of the AKT-mTOR signaling pathway. Overall, our study here suggests that natural bioactive compound curcumin could alleviate arsenic-induced pulmonary oxidative stress and inflammation in vivo, which is closely related to enhanced TFEB activity and induction of the autophagic process.
科研通智能强力驱动
Strongly Powered by AbleSci AI