内皮功能障碍
分子成像
糖尿病
生物信息学
超声波
医学
鉴定(生物学)
内皮
内科学
内分泌学
放射科
生物
生物技术
体内
植物
作者
J Liu,Chen Wang,Shuang-jian Qiu,Wenqi Sun,Guodong Yang,Lijun Yuan
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2024-02-23
卷期号:7 (3): 1416-1428
标识
DOI:10.1021/acsabm.4c00053
摘要
Diabetes vasculopathy is a significant complication of diabetes mellitus (DM), and early identification and timely intervention can effectively slow the progression. Accumulating studies have shown that diabetes causes vascular complications directly or indirectly through a variety of mechanisms. Direct imaging of the endothelial molecular changes not only identifies the early stage of diabetes vasculopathy but also sheds light on the precise treatment. Targeted ultrasound contrast agent (UCA)-based ultrasound molecular imaging (UMI) can noninvasively detect the expression status of molecular biomarkers overexpressed in the vasculature, thereby being a potential strategy for the diagnosis and treatment response evaluation of DM. Amounts of efforts have been focused on identification of the molecular targets expressed in the vasculature, manufacturing strategies of the targeted UCA, and the clinical translation for the diagnosis and evaluation of therapeutic efficacy in both micro- and macrovasculopathy in DM. This review summarizes the latest research progress on endothelium-targeted UCA and discusses their promising future and challenges in diabetes vasculopathy theranostics.
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