In recent years, substantial advancements have been made in the field of wearable flexible sensors. These sensors possess elasticity and conformability, coupled with enhanced data collection and processing capabilities, which lead to increases in hardware performance and significant enhancements in software data processing capabilities. These sensors can precisely measure a wide range of human physiological parameters, including heart rate, respiration, temperature, blood glucose levels, muscle activity, and ion concentrations in sweat. Beyond their fundamental functions, these sensors can transmit data in real time through wireless transmission modules. Therefore, these sensors are highly valuable for sports monitoring, and have considerable potential for personal healthcare and medical systems. This review comprehensively summarizes recent advancements in material innovation, stretchable structural designs, and energy integration technology breakthroughs in wearable flexible sensors. The applications in motion monitoring are systematically categorized by signal type into physical, chemical, and electrophysiological sensors. Finally, challenges in wearable flexible sensors for motion monitoring are discussed, and feasible strategies are proposed to guide future research.