Preparation of Chiral α-Aryl Ketones and Aldehydes via Ni-Catalyzed Asymmetric Cross-Electrophile Coupling

Abstract The preparation of tertiary α-aryl acetals and ketals has been achieved through a Ni-catalyzed reductive cross-coupling approach, utilizing a readily available Ni/Biox catalytic platform. This reaction demonstrates effective enantioselective control over unactivated alkyl radicals adjacent to sterically bulky acetal and ketal groups. The resulting protected tertiary α-aryl ketones and aldehydes are configurationally stable, offering opportunities for further chemical manipulations.