肌萎缩
线粒体生物发生
小RNA
骨骼肌
功能(生物学)
生物信息学
线粒体
生物
医学
计算生物学
细胞生物学
内分泌学
生物化学
基因
作者
Yufeng Long,Simon Kwoon‐Ho Chow,Can Cui,Ronald Man Yeung Wong,Ning Zhang,Ling Qin,Sheung Wai Law,Wing-Hoi Cheung
标识
DOI:10.1016/j.arr.2023.102048
摘要
Sarcopenia is the accelerated loss of muscle mass, strength and function. Mitochondrial dysfunction was related to the progression of sarcopenia; meanwhile, microRNAs were regarded as core roles in regulating mitochondrial function. Physical exercise is a well-accepted approach to attenuate sarcopenia, yet very few studies depict the molecular mechanisms. The aim of this systematic review is to explore the potential relationships among physical exercise, mitochondrial function, and microRNAs, which may give new insight for retarding sarcopenia. A systematic literature search was performed in PubMed, Embase and Web of Science. The keywords were combined as “(microRNA OR miR) AND mitochondri* AND muscle AND exercise” and searched in all fields. PRISMA guidelines were followed. Information was extracted from the included studies for review. In this review, 18 preclinical studies and 5 clinical studies were included. Most of the included studies suggested that effective physical exercise had positive effects on mitochondrial functions by regulating microRNAs. The results showed that 12 microRNAs improved mitochondrial functions, while 18 microRNAs suppressed them. Meanwhile, the results showed that 5 microRNAs improved muscle performance. This systematic review provides an up-to-date sequential overview and highlights the potential relationship among exercise, mitochondrial function, and microRNAs in muscle. Meanwhile, evidence revealed that physical exercise can improve muscle performance by up-regulating mitochondrial functions, especially mitochondrial biogenesis, through modulating microRNAs.
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