化学
对映选择合成
亚胺
吲哚嗪
磺胺
弗里德尔-克拉夫茨反应
磺酰
磷酸
催化作用
有机化学
组合化学
烷基
作者
Parbat Subba,Milon M Sadhu,Vinod K. Singh
标识
DOI:10.1021/acs.joc.3c01686
摘要
A highly efficient chiral phosphoric acid-catalyzed enantioselective Friedel–Crafts addition of indolizine to cyclic N-sulfonyl imine has been established. The newly developed protocol, which probably proceeds via a monoactivation reaction pathway, allows the access of enantioenriched sulfonamide functionalized indolizines with excellent yields (up to 99%) and enantioselectivities (up to 99%). Moreover, the synthetic utility of this protocol has been explored with some chemical transformations.
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