Regioselective Synthesis of β-Silyl-Substituted Vinylphosphine Oxides via Copper-Catalyzed Protosilylation of Dialkynylphosphine Oxides

A copper-catalyzed mono-lateral protosilylation of dialkynylphosphine oxides for the synthesis of β-silyl substituted vinylphosphine oxides is described.Various (hetero)aryl and alkyl-substituted diynes afforded the corresponding products in moderate and high yields with high chemoselectivity.An alternative alkynyl functional group of products could also be further derived.