转录组
黑色素瘤
表型
生物
氧化应激
细胞内
癌症研究
细胞生物学
基因
基因表达
遗传学
生物化学
作者
Xingjian Zhang,Xiaoyi Shi,Dingyao Zhang,Xiangyu Gong,Wen Zhang,Israel Demandel,Junqi Zhang,Alejandro Rossello‐Martinez,Trevor J. Chan,Michael Mak
标识
DOI:10.1073/pnas.2220062120
摘要
Physical forces are prominent during tumor progression. However, it is still unclear how they impact and drive the diverse phenotypes found in cancer. Here, we apply an integrative approach to investigate the impact of compression on melanoma cells. We apply bioinformatics to screen for the most significant compression-induced transcriptomic changes and investigate phenotypic responses. We show that compression-induced transcriptomic changes are associated with both improvement and worsening of patient prognoses. Phenotypically, volumetric compression inhibits cell proliferation and cell migration. It also induces organelle stress and intracellular oxidative stress and increases pigmentation in malignant melanoma cells and normal human melanocytes. Finally, cells that have undergone compression become more resistant to cisplatin treatment. Our findings indicate that volumetric compression is a double-edged sword for melanoma progression and drives tumor evolution.
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