医学
改良兰金量表
析因分析
冲程(发动机)
内科学
缺血性中风
随机对照试验
心脏病学
缺血
机械工程
工程类
作者
Yu Cui,Zhi-Mei Yuan,Quanying Liu,Ying-Jia Wang,Hui‐Sheng Chen
出处
期刊:Stroke
[Ovid Technologies (Wolters Kluwer)]
日期:2023-12-01
卷期号:54 (12): 3165-3168
被引量:1
标识
DOI:10.1161/strokeaha.123.045040
摘要
RICAMIS trial (The Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke) has demonstrated efficacy of remote ischemic conditioning (RIC) in acute ischemic stroke. We conducted a post hoc analysis of RICAMIS to investigate whether large artery atherosclerosis (LAA) subtype contributed to the outcomes.This is a post hoc analysis of the RICAMIS trial. Patients randomized to RIC group and Control group in full analysis set of RICAMIS were classified into LAA and non-LAA subtypes. The primary outcome was excellent functional outcome at 90 days, defined as modified Rankin Scale score of 0 to 1. Compared with patients receiving usual care, we investigated the association of RIC effect with outcomes in stroke subtypes and the interaction between RIC effect and stroke subtypes. The primary analysis was adjusted analysis.Among 1773 patients, 516 were assigned to LAA subtype (229 in the RIC group and 287 in the control group) and 1257 to non-LAA subtype (633 in the RIC group and 624 in the control group). Median age was 65 years, and 34.2% were women. A higher proportion of primary outcome was found to be associated with RIC treatment in LAA subtype (adjusted risk difference, 11.4% [95% CI, 3.6%-19.2%]; P=0.004), but not in non-LAA subtype (adjusted risk difference, 4.1% [95% CI, -1.1% to 9.3%]; P=0.12). There was no significant interaction between RIC effect and stroke subtypes (P=0.12).Patients with LAA subtype may benefit from RIC after stroke with respect to excellent functional outcome at 90 days.URL: https://www.clinicaltrials.gov; Unique identifier: NCT03740971.
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