纳米医学
光热治疗
癌症研究
三阴性乳腺癌
上睑下垂
纳米载体
体内
阿霉素
免疫系统
材料科学
普鲁士蓝
癌细胞
细胞毒性T细胞
细胞毒性
癌症
药理学
乳腺癌
体外
医学
药物输送
纳米技术
程序性细胞死亡
化学
免疫学
细胞凋亡
化疗
生物
纳米颗粒
内科学
生物化学
生物技术
物理化学
电化学
电极
作者
Ying Long,Jialong Fan,Naduo Zhou,Jiahao Liang,Chang Xiao,Chunyi Tong,Wei Wang,Bin Liu
出处
期刊:Biomaterials
[Elsevier]
日期:2023-12-01
卷期号:303: 122369-122369
被引量:3
标识
DOI:10.1016/j.biomaterials.2023.122369
摘要
Drug-induced immunogenic cell death (ICD) can efficiently inhibit tumor growth and recurrence through the release of tumor-associated antigens which activate both local and systemic immune responses. Pyroptosis has emerged as an effective means for inducing ICD; however, the development of novel pyroptosis inducers to specifically target tumor cells remains a pressing requirement. Herein, we report that Cinobufagin (CS-1), a main ingredient of Chansu, can effectively induce pyroptosis of triple-negative breast cancer (TNBC) cells, making it a potential therapeutic agent for this kind of tumor. However, the application of CS-1 in vivo is extremely limited by the high dosage/long-term usage and non-selectivity caused by systemic toxicity. To address these drawbacks, we developed a new nanomedicine by loading CS-1 into Prussian blue nanoparticles (PB NPs). The nanomedicine can release CS-1 in a photothermal-controlled manner inherited in PB NPs. Furthermore, hybrid membrane (HM) camouflage was adopted to improve the immune escape and tumor-targeting ability of this nanomedicine, as well. In vitro assays demonstrated that the chemo-photothermal combination treatment produced high-level ICD, ultimately fostering the maturation of dendritic cells (DCs). In vivo anti-tumor assessments further indicated that this strategy not only efficiently inhibited primary growth of MDA-MB-231 cells and 4T1 cells-bearing models but also efficiently attenuated distant tumor growth in 4T1 xenograft model. This was mechanistically achieved throuh the promotion of DCs maturation, infiltration of cytotoxic T lymphocyte into the tumor, and the inhibition of Treg cells. In summary, this work provides a novel strategy for efficient TNBC therapy by using nanomaterials-based multimodal nanomedicine through rational design.
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