化学
亲水作用色谱法
甲基丙烯酸缩水甘油酯
选择性
洗脱
二乙烯基苯
色谱法
酰胺
聚合物
甲基丙烯酸酯
聚合
高分子化学
有机化学
高效液相色谱法
共聚物
苯乙烯
催化作用
作者
Ziteng Yu,Zongying Li,Feifang Zhang,Bingcheng Yang
标识
DOI:10.1016/j.chroma.2023.464328
摘要
A novel polymer-based polar stationary phase for hydrophilic interaction chromatography (HILIC) is described. It was obtained by grafting lysine and acrylamide onto poly (glycidyl methacrylate-divinylbenzene) (GMA-DVB) microspheres via ring-opening reaction of epoxy groups and free radical polymerization with pendant double bonds of the microspheres. Multiple types of polar groups including zwitterionic (carboxylate and amine), amide and diol onto the microspheres make them highly hydrophilic. It showed typical HILIC character and good separation performance towards model polar analytes. Negligible bleed level under gradient elution mode (up to 50% fraction of water) was observed. It also exhibited specific separation selectivity to ionic analytes and simultaneous separation of anions and cations could be achieved in ideal electrostatic selectivity elution order, e.g. I−< NO3−
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