光热治疗
生物相容性
活性氧
纳米颗粒
肿瘤微环境
体内
乙二醇
谷胱甘肽
PEG比率
化学
癌症研究
纳米技术
材料科学
生物物理学
肿瘤细胞
生物化学
医学
生物
生物技术
有机化学
财务
经济
酶
作者
Runrun Shao,Xi Qiao,Lixin Cao,Jianliang Man,Lei Guo,Lanlan Li,Wen Liu,Lihong Li,Bin Wang,Lixia Guo,Sufang Ma,Boye Zhang,Haojiang Wang,Lili Yan
标识
DOI:10.1186/s11671-023-03902-9
摘要
The development of nanoparticles capable of inducing reactive oxygen species (ROS) formation has become an important strategy for cancer therapy. Simultaneously, the preparation of multifunctional nanoparticles that respond to the tumor microenvironment is crucial for the diagnosis and treatment of tumors. In this study, we designed a Molybdenum disulfide (MoS2) core coated with Manganese dioxide (MnO2), which possessed a good photothermal effect and could produce Fenton-like Mn2+ in response to highly expressed glutathione (GSH) in the tumor microenvironment, thereby generating a chemodynamic therapy (CDT). The nanoparticles were further modified with Methoxypoly(Ethylene Glycol) 2000 (mPEG-NH2) to improve their biocompatibility, resulting in the formation of MoS2@MnO2-PEG. These nanoparticles were shown to possess significant Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) imaging capabilities, making them useful in tumor diagnosis. In vitro and in vivo experiments demonstrated the antitumor ability of MoS2@MnO2-PEG, with a significant killing effect on tumor cells under combined treatment. These nanoparticles hold great potential for CDT/photothermal therapy (PTT) combined antitumor therapy and could be further explored in biomedical research.
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