乳腺
免疫系统
哺乳期
激素
分泌性IgA
淋巴系统
生物
肠系膜淋巴结
淋巴
内分泌学
抗原
怀孕
内科学
免疫学
医学
病理
遗传学
癌症
乳腺癌
作者
Michael E. Lamm,Paul Weisz-Carrington,M Roux,Michael McWilliams,Julia M. Phillips‐Quagliata
标识
DOI:10.1007/978-1-4684-3369-2_5
摘要
1) Lymphoblasts in gut-associated lymphoid tissue, committed to the production of IgA, can home to the mammary glands of syngeneic mice and differentiate there into IgA-containing plasmablasts. The phenomenon is limited to near term and lactating recipients. 2) The ability of lymphocytes originating in gut-associated lymphoid tissue and sensitized to intestinal antigens to migrate to the mammary gland can account for the specificity of milk IgA toward intestinal microorganisms and the consequent passive protection offered to suckling infants. 3) The secretory immune system of the mammary gland is apparently under hormonal control since mammotropic hormones given to virgin females can induce morphological and functional characteristics seen naturally only during pregnancy and lactation. Examples are increased numbers of IgA plasma cells and the ability to trap their circulating precursors taken from mesenteric lymph nodes.
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