Abstract 1448: Enhanced Foam Cell Formation, Inflammation, and Atherosclerosis in LDL Receptor knockout Mice with a Combined Deletion of Macrophage SR-BI and ABCA1.

ABCA1 mediates the efflux of cholesterol from macrophage foam cells to lipid-poor apoAI, while SR-BI promotes efflux to mature HDL. To get further insight into the putative synergistic roles of ABC...