去整合素
毒液
整合素
糖蛋白
纤维蛋白原
受体
蛇毒
生物
细胞生物学
化学
生物化学
金属蛋白酶
基质金属蛋白酶
作者
Stefan Niewiarowski,McLane Ma,M Kłoczewiak,Stewart Gj
出处
期刊:PubMed
日期:1994-10-01
卷期号:31 (4): 289-300
被引量:48
摘要
Disintegrins represent a family of low-molecular weight, cysteine-rich, RGD-containing peptides that inhibit fibrinogen binding to glycoprotein IIb/IIIa complex as well as binding of other ligands to RGD-dependent integrins on the surface of other cells. Disintegrins occur in the venom of various vipers. Disintegrin domains have been identified in viper venom hemorrhagins and in sperm proteins involved in the sperm-egg fusion. Amino acid sequences of 25 disintegrins, alignment of S-S bridges in four disintegrins, and stereo models of five disintegrins are presented. Primary structures of disintegrins differ significantly from other fibrinogen receptor antagonists occurring in the venoms of Elapidae, leeches, and ticks. Several aspects of structure-function relationship of disintegrins, their biological activities, and possible clinical applications are discussed.
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