Long-term Intermittent Hypoxia in Mice: Protracted Hypersomnolence with Oxidative Injury to Sleep-Wake Brain Regions

Study Objectives:This study was designed to test the hypothesis that long-term intermittent hypoxia (LTIH), modeling the hypoxia-reoxygenation events of sleep apnea, results in oxidative neural injury, including wake-promoting neural groups, and that this injury contributes to residual impaired maintenance of wakefulness.