抗酸剂
硫糖铝
消胆胺
镁
胆汁酸
氢氧化物
吸附
化学
氢氧化铝
无机化学
核化学
医学
铝
生物化学
有机化学
胆固醇
作者
M Ståhlberg,P. Jalovaara,S Laitinen,R Mokka,R Hentilä,P Järvensivu,Matti I. Kairaluoma
出处
期刊:PubMed
日期:1987-01-01
卷期号:9 (6): 615-21
被引量:3
摘要
Sucralfate, one of the newer drugs shown to be effective in the treatment of peptic ulcer and esophagitis; cholestyramine, a known bile acid binder; and commercial antacid preparations of pure aluminum hydroxide, pure magnesium hydroxide, and a combination of aluminum hydroxide, magnesium hydroxide, and magnesium carbonate were tested in vitro for bile acid-binding capacity. Cholestyramine was found to be the most effective bile acid binder, with more than 90% of bile acids adsorbed at all of the pH values studied. Sucralfate proved efficacious at pH 4, 6, and 8, adsorbing about 50% of the bile acids, but its binding capacity decreased at pH 2. Pure aluminum hydroxide was the most effective of the various antacid preparations; it adsorbed about 90% of bile acids at pH 2, although this percentage was significantly reduced at pH 6 and 8. Sucralfate was significantly more effective as a bile acid absorbent at pH 4 than either the magnesium hydroxide or aluminum-magnesium hydroxide plus magnesium carbonate antacids, as effective as the aluminum hydroxide antacid, and significantly less effective than cholestyramine.
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