代谢综合征
内科学
炎症
生物标志物
血清淀粉样蛋白A
脂蛋白(a)
血脂异常
胆固醇
载脂蛋白B
国家胆固醇教育计划
内分泌学
C反应蛋白
糖尿病
作者
Juan Francisco Sánchez Muñoz-Torrero,Dolores Rivas,Rodrigo Alonso,Leandro Crespo,Alberto Costo,Montaña Roman,Carlos Martín,José Luis Zamorano
标识
DOI:10.1097/smj.0b013e31825b5fb2
摘要
OBJECTIVE To examine the relation between plasma lipoprotein (a) (Lp[a]) levels and oxidative stress biomarkers, serum cytokines, and atherosclerotic burden among individuals recently diagnosed as having metabolic syndrome (MS). METHODS Eighty-four white patients with MS were classified according to two Lp(a) levels (normal Lp[a]: 30 mg/dL) and were compared with 42 healthy controls. Oxidative stress biomarkers (oxidized low-density lipoprotein, antibodies to oxidized low-density lipoprotein, and nitric oxide metabolites) and proinflammatory cytokines (interleukin [IL]-2, IL-4, IL-5, IL-6, IL-10, IL-12P70, IL-13, and interferon-γ) were measured in plasma. Atherosclerotic significance was determined using carotid ultrasound and endothelial function by standardized protocols. RESULTS Patients with MS had higher levels of serum cytokines, oxidative stress markers, and C-reactive protein, and greater atherosclerosis burden as compared with controls. Among the group members, 58 patients had normal Lp(a) levels and 26 had high Lp(a) levels. Cytokines and C-reactive protein levels were significantly higher in patients with high Lp(a) compared with those with normal Lp(a) (P < 0.01 for IL-2 and P < 0.001 for the others). Nitric oxide metabolites were significantly lower in patients with high Lp(a) as compared with those with normal Lp(a) (P < 0.05). No differences were found in oxidized low-density lipoprotein and atherosclerotic burden between the two groups of patients with MS with respect to Lp(a) levels. CONCLUSIONS Elevated Lp(a) plasma levels are associated with higher proinflammatory markers in patients newly diagnosed as having MS.
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