建模者
计算生物学
计算机科学
蛋白质结构预测
构造(python库)
蛋白质结构
序列(生物学)
同源建模
生物信息学
生物
遗传学
程序设计语言
生物化学
酶
作者
Narayanan Eswar,David Eramian,Ben Webb,Min-Yi Shen,Andrej Šali
出处
期刊:Methods in molecular biology
日期:2008-01-01
卷期号:: 145-159
被引量:1270
标识
DOI:10.1007/978-1-60327-058-8_8
摘要
Genome sequencing projects have resulted in a rapid increase in the number of known protein sequences. In contrast, only about one-hundredth of these sequences have been characterized using experimental structure determination methods. Computational protein structure modeling techniques have the potential to bridge this sequence-structure gap. This chapter presents an example that illustrates the use of MODELLER to construct a comparative model for a protein with unknown structure. Automation of similar protcols has resulted in models of useful accuracy for domains in more than half of all known protein sequences.
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