介孔二氧化硅
材料科学
纳米技术
纳米颗粒
药物输送
介孔材料
介孔有机硅
有机化学
化学
催化作用
标识
DOI:10.1016/j.actbio.2021.10.011
摘要
Our contributions to mesoporous silica materials in the field of biomedicine are reported in this article. This perspective article represents our work in the basics of the material, preparing different ranges of mesoporous silica nanoparticles with different diameters and with varied pore sizes. We demonstrated the high loading capacity of these materials. Additionally, the possibility of functionalizing both internal and external surface with different organic or inorganic moieties allowed the development of stimuli-responsive features which allowed a proper control on the administered dose. In addition, we have demonstrated that these carriers are not toxic, and we have also ensured that the load reaches its destination without affecting healthy tissues. STATEMENT OF SIGNIFICANCE: This paper presents my personal opinion and background on a hot topic as mesoporous silica nanoparticles for drug delivery. To this aim it provides a comprehensive and historical overview on the innovative contributions of my research group to this rapidly expanding field of research.
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