喷雾干燥
工艺工程
制药工业
过程(计算)
关键质量属性
新产品开发
纳米技术
设计质量
生化工程
质量(理念)
过程分析技术
材料科学
业务
计算机科学
生物技术
在制品
工程类
化学
营销
色谱法
生物
哲学
操作系统
认识论
作者
John A. Baumann,Molly S. Adam,Joel Wood
标识
DOI:10.1146/annurev-chembioeng-091720-034106
摘要
Spray drying is a versatile technology that has been applied widely in the chemical, food, and, most recently, pharmaceutical industries. This review focuses on engineering advances and the most significant applications of spray drying for pharmaceuticals. An in-depth view of the process and its use is provided for amorphous solid dispersions, a major, growing drug-delivery approach. Enhanced understanding of the relationship of spray-drying process parameters to final product quality attributes has made robust product development possible to address a wide range of pharmaceutical problem statements. Formulation and process optimization have leveraged the knowledge gained as the technology has matured, enabling improved process development from early feasibility screening through commercial applications. Spray drying's use for approved small-molecule oral products is highlighted, as are emerging applications specific to delivery of biologics and non-oral delivery of dry powders. Based on the changing landscape of the industry, significant future opportunities exist for pharmaceutical spray drying.
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