材料科学
银纳米粒子
纳米颗粒
化学工程
光热效应
抗菌活性
复合数
核化学
纳米技术
光热治疗
化学
复合材料
细菌
遗传学
生物
工程类
作者
Tianyu Zhang,Dongdong Zhu,Wanni Wang,Haisheng Qian,Zhaoyou Chu,Chen Ben-jing,Juan Ruan,Min Shao,Zhengbao Zha
标识
DOI:10.1166/jbn.2021.3099
摘要
In this study, we have described a facile process for fabrication of multifunctional composite hydrogel, in which sodium alginate was subjected to cross-linking using Ca 2+ derived from ZnO/CaCO 3 /Ag composite nanospheres. The ZnO/CaCO 3 /Ag composite nanospheres were prepared based on our previously reported AA-[Zn(OH) 4 ] 2− composite nanosphere reaction conducted with silver and calcium salt following hydrothermal method, that led to the disintegration and release of Ca 2+ under acidic conditions for application as a cross-linking agentto catalyze reaction with sodium alginate. Ag nanoparticles were well-dispersed in the multifunctional composite hydrogel, exhibiting excellent antibacterial activity. Additionally, polydopamine (PDA) with photothermal effect was also added to obtain a multifunctional composite hydrogel, and this hydrogel showed photothermal conversion performance and facilitated the release of Ag + to achieve the rapid antibacterial effect. Simultaneously, PDA NPs could scavenge free radicals and improve cell adhesion. All such features would promote wound healing. The potent antimicrobial activity of the prepared composite hydrogel was demonstrated in the mouse model of S. aureus infection, and biosafety of the hydrogel was confirmed by conducting histopathological examination in the mouse model. This type of multifunctional hydrogel wound dressing with photosensitive and antibacterial properties presents with broad applications and prospects in antibacterial treatment.
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