医学
接收机工作特性
尿
膀胱癌
癌症
泌尿系统
内科学
泌尿科
肿瘤科
妇科
作者
Won Ho Kim,Pildu Jeong,Chunri Yan,Ye An Kim,Il-Seok Lee,Ho-Won Kang,Yong-June Kim,Sang-Cheol Lee,Sang Hoon Kim,Yong Jin Kim,Sung-Kwon Moon,Yung Hyun Choi,Wun-Jae Kim,Seok Hyun Yun,Wun-Jae Kim
出处
期刊:Oncotarget
[Impact Journals, LLC]
日期:2016-08-12
卷期号:7 (36): 58193-58202
被引量:27
标识
DOI:10.18632/oncotarget.11277
摘要
There is growing interest in circulating nucleic acids as cancer detection biomarkers. Therefore, the aim of the present study was to identify a key urinary cell-free RNA marker that may assist in the diagnosis of BC.Five cell-free RNAs were selected as candidate cell-free RNAs from tissue microarray data. An area under the curve (AUC) cut-off value of 0.7 in receiver operating characteristic (ROC) curve analysis identified four urinary cell-free RNAs for further analysis (CDC20, ESM1, UBE2C, and CA9; AUC = 0.716, 0.704, 0.721, and 0.702, respectively). Binary logistic regression analysis revealed that high expression of UBE2C was significantly associated with BC (OR, 1.754; CI, 1.147-2.682; p = 0.010). Analysis of UBE2C expression in urine samples from BC patients and hematuria controls yielded an AUC of 0.839, with a sensitivity of 82.5% and a specificity of 76.2%. UBE2C levels was significantly increased in G2 and G3 tumors compared to normal controls (p <0.001, respectively).Urine samples from 212 BC patients and 106 normal controls (64 healthy individuals and 42 with hematuria) were examined. The candidate cell-free RNAs identified from tissue microarrays derived from BC and normal control tissues was then measured in the urine samples.The levels of urinary UBE2C cell-free RNA were significantly higher in BC samples than in normal and hematuria control samples. The higher levels of urinary UBE2C cell-free RNA in BC might reflect high expression in BC tissues. Therefore, urinary UBE2C cell-free RNA may be a valuable diagnostic marker for BC.
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