体内
芦丁
自愈水凝胶
药物输送
材料科学
药理学
药品
控制释放
体外
生物物理学
生物化学
化学
纳米技术
医学
抗氧化剂
生物
高分子化学
生物技术
作者
Hongyue Wang,Lin Wang,Shasha Guo,Zehao Liu,Luqing Zhao,Renzhong Qiao,Chao Li
标识
DOI:10.1021/acsami.2c02295
摘要
An active flavonoid compound rutin was incorporated into a guanosine phenylborate hydrogel (GBR) by a stimuli-responsive borate ester linkage for the treatment of inflammatory bowel disease (IBD). The components and morphology of the drug delivery system were characterized by NMR, UV-vis spectroscopy, and AFM. Rheological measurements revealed the required injectability and self-healing ability, which contributed to its application in rectal administration. The cell assays proved the excellent compatibility and safety of the system, and a possible pathway to form multicellular aggregates. In vitro drug-release studies showed that the hydrogel exhibited good stability in physiological medium, and the drug was almost completely released (more than 90 wt % after 24 h of incubation) in acidic pH and excessive ROS-containing medium, realizing the dual-responsive release of pH/ROS. In vivo activities of the GBR hydrogel showed higher therapeutic efficacy than free rutin in a colitis mice model, and it could significantly inhibit overexpressed inflammatory cytokines, including TNF-α and IL-6. Degradation studies of the hydrogel provided further evidence for the safety of its in vivo application. The work provided a simple strategy to prepare a G-quadruplex drug carrier, which was expected to achieve multi-drug delivery.
科研通智能强力驱动
Strongly Powered by AbleSci AI