去卵巢大鼠
兰克尔
骨质疏松症
内分泌学
内科学
雌激素
骨矿物
H&E染色
股骨
医学
骨重建
骨保护素
化学
免疫组织化学
受体
外科
激活剂(遗传学)
作者
Yixin ZHU,Shuxiu JIN,Ding ZHANG,Zhuo DUAN,Donghao ZHAO,Keguang Han,Shaopeng Gu,Ли Тао,Nairui Huo
摘要
Sheep bone collagen peptide (SBCP) has attracted attention due to its potential effects on bone health. This study aims to explore the bone protective effect of SBCP in the presence of estrogen deficiency. Ovariectomized (OVX) female rats were given different dose rates (0, 0.68, 2.05, 3.40 g/kg BW) of SBCP for 8 consecutive weeks. At the end of the treatment, the serological indexes and tibial mineral content were measured. The microstructure and morphological changes of femur bones were observed by scanning electron microscopy (SEM) and hematoxylin and eosin (H & E) staining. Femur bones were harvested for determination of expression level of RANK, RANKL, OPG by molecular biological techniques. 3.40 g/kg BW SBCP treatment decreased the PINP and β-CTx levels but increased the tibial calcium and phosphorus contents significantly in estrogen deficient rats. Expression of RANK and RANKL decreased however expression of OPG increased in the bone of estrogen deficient rats which received 3.40 g/kg BW SBCP with greater effects than SBCP-M and SBCP-L treatments. SBCP helps to overcome the adverse effect of estrogen deficiency the bone and thus this nutriment could potentially be used for the treatment and prevention of osteoporosis in postmenopausal women.
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