化学
对映选择合成
组合化学
基质(水族馆)
功能群
催化作用
配体(生物化学)
替代(逻辑)
范围(计算机科学)
立体化学
有机化学
生物化学
海洋学
聚合物
受体
计算机科学
程序设计语言
地质学
作者
Hao-Dong Qian,Zhiheng Li,Shuang Deng,Chaochao Yao,Hua-Ming Xiang,Guang Xu,Zi-Qi Geng,Zihao Wang,Linfeng Chen,Chunrong Liu,Cancan Zhu,Xiaotian Qi,Hao Xu
摘要
Distinct regio- and enantioselectivity control in copper-catalyzed vinylogous and bisvinylogous propargylic substitution has been accomplished by using a novel chiral N,N,P ligand. The developed method provides an efficient and selective approach to an array of highly enantioenriched alkynyl unsaturated carbonyl compounds. Salient features include excellent functional group tolerance and broad substrate scope. The synthetic utility of the developed method is further demonstrated by a gram-scale synthesis and by application to a range of transformations including enantioselective synthesis of unique challenging compounds.
科研通智能强力驱动
Strongly Powered by AbleSci AI