Imaging Caveats to Consider When Screening for Thrombolysis in the Extended Time Window

HomeStrokeVol. 54, No. 7Imaging Caveats to Consider When Screening for Thrombolysis in the Extended Time Window No AccessCase ReportRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessCase ReportRequest AccessFull TextImaging Caveats to Consider When Screening for Thrombolysis in the Extended Time Window Dennys Reyes, Sabrena M. Ahmadi, Stuart Kieran, Nils H. Mueller-Kronast, Scott E. Blumenthal, Shlee S. Song and Alexis N. Simpkins Dennys ReyesDennys Reyes Delray Medical Center, Delray Beach, FL (D.R., S.K., N.H.M.-K., S.E.B.). Search for more papers by this author , Sabrena M. AhmadiSabrena M. Ahmadi Department of Vascular Neurology, Cedars Sinai Medical Center, Los Angeles, CA (S.M.A., S.S.S., A.N.S.). Search for more papers by this author , Stuart KieranStuart Kieran https://orcid.org/0009-0006-8083-8584 Delray Medical Center, Delray Beach, FL (D.R., S.K., N.H.M.-K., S.E.B.). Search for more papers by this author , Nils H. Mueller-KronastNils H. Mueller-Kronast Delray Medical Center, Delray Beach, FL (D.R., S.K., N.H.M.-K., S.E.B.). Search for more papers by this author , Scott E. BlumenthalScott E. Blumenthal Delray Medical Center, Delray Beach, FL (D.R., S.K., N.H.M.-K., S.E.B.). Search for more papers by this author , Shlee S. SongShlee S. Song https://orcid.org/0000-0002-7838-0205 Department of Vascular Neurology, Cedars Sinai Medical Center, Los Angeles, CA (S.M.A., S.S.S., A.N.S.). Search for more papers by this author and Alexis N. SimpkinsAlexis N. Simpkins Correspondence to: Alexis N. Simpkins, MD, PhD, MSCR, Director of Vascular Neurology Research and the SkRIPT Research Program, Department Neurology, 127 S San Vicente Blvd, Los Angeles, CA 90048. Email E-mail Address: [email protected] https://orcid.org/0000-0001-7529-4267 Department of Vascular Neurology, Cedars Sinai Medical Center, Los Angeles, CA (S.M.A., S.S.S., A.N.S.). Department of Neurology, University of Florida College of Medicine, Gainesville (A.N.S.). Search for more papers by this author Originally published15 May 2023https://doi.org/10.1161/STROKEAHA.122.042019Stroke. 2023;54:e310–e313FootnotesFor Sources of Funding and Disclosures, see page e313.Correspondence to: Alexis N. Simpkins, MD, PhD, MSCR, Director of Vascular Neurology Research and the SkRIPT Research Program, Department Neurology, 127 S San Vicente Blvd, Los Angeles, CA 90048. Email alexis.simpkins@cshs.orgReferences1. Sussman BJ, Fitch TS. Thrombolysis with fibrinolysin in cerebral arterial occlusion.J Am Med Assoc. 1958; 167:1705–1709. doi: 10.1001/jama.1958.02990310011002CrossrefMedlineGoogle Scholar2. Schwamm LH, Wu O, Song SS, Latour LL, Ford AL, Hsia AW, Muzikansky A, Betensky RA, Yoo AJ, Lev MH, et al; MR WITNESS Investigators. Intravenous thrombolysis in unwitnessed stroke onset: MR WITNESS trial results.Ann Neurol. 2018; 83:980–993. doi: 10.1002/ana.25235CrossrefMedlineGoogle Scholar3. Thomalla G, Simonsen CZ, Boutitie F, Andersen G, Berthezene Y, Cheng B, Cheripelli B, Cho TH, Fazekas F, Fiehler J, et al; WAKE-UP Investigators. MRI-guided thrombolysis for stroke with unknown time of onset.N Engl J Med. 2018; 379:611–622. doi: 10.1056/NEJMoa1804355CrossrefMedlineGoogle Scholar4. Simpkins AN, Tahsili-Fahadan P, Buchwald N, De Prey J, Farooqui A, Mugge LA, Ranasinghe T, Senetar AJ, Echevarria FD, Alvi MM, et al. Adapting clinical practice of thrombolysis for acute ischemic stroke beyond 4.5 hours: a review of the literature.J Stroke Cerebrovasc Dis. 2021; 30:106059. doi: 10.1016/j.jstrokecerebrovasdis.2021.106059CrossrefGoogle Scholar5. Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the american heart association/american stroke association.Stroke. 2019; 50:e344–e418. doi: 10.1161/STR.0000000000000211LinkGoogle Scholar6. Barreto AD, Fanale CV, Alexandrov AV, Gaffney KC, Vahidy FS, Nguyen CB, Sarraj A, Rahbar M, Grotta JC, Savitz SI, et al; Wake-Up Stroke Investigators. Prospective, open-label safety study of intravenous recombinant tissue plasminogen activator in wake-up stroke.Ann Neurol. 2016; 80:211–218. doi: 10.1002/ana.24700CrossrefMedlineGoogle Scholar7. Urrutia VC, Faigle R, Zeiler SR, Marsh EB, Bahouth M, Cerdan Trevino M, Dearborn J, Leigh R, Rice S, Lane K, et al. Safety of intravenous alteplase within 4.5 hours for patients awakening with stroke symptoms.PLoS One. 2018; 13:e0197714. doi: 10.1371/journal.pone.0197714CrossrefMedlineGoogle Scholar8. Jensen M, Sehner S, Cheng B, Schlemm E, Quandt F, Barow E, Wegscheider K, Boutitie F, Ebinger M, Endres M, et al. Patient-reported quality of life after intravenous alteplase for stroke in the WAKE-UP trial.Neurology. 2023; 100:e154–e162. doi: 10.1212/WNL.0000000000201375CrossrefGoogle Scholar9. Ma H, Campbell BCV, Parsons MW, Churilov L, Levi CR, Hsu C, Kleinig TJ, Wijeratne T, Curtze S, Dewey HM, et al; EXTEND Investigators. Thrombolysis guided by perfusion imaging up to 9 hours after onset of stroke.N Engl J Med. 2019; 380:1795–1803. doi: 10.1056/NEJMoa1813046CrossrefMedlineGoogle Scholar10. Kim-Tenser M, Mlynash M, Lansberg MG, Tenser M, Bulic S, Jagadeesan B, Christensen S, Simpkins A, Albers GW, Marks MP, et al. CT perfusion core and ASPECT score prediction of outcomes in DEFUSE 3.Int J Stroke. 2021; 16:288–294. doi: 10.1177/1747493020915141CrossrefGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetails July 2023Vol 54, Issue 7 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/STROKEAHA.122.042019PMID: 37183685 Originally publishedMay 15, 2023 Keywordsmagnetic resonance imagingbrain imagingischemic strokethrombolytic therapyPDF download Advertisement SubjectsCerebrovascular Disease/StrokeIschemic Stroke