医学
肺动脉高压
内科学
慢性血栓栓塞性肺高压
心脏病学
生活质量(医疗保健)
肺动脉
血流动力学
血管成形术
慢性阻塞性肺病
血管阻力
气球
物理疗法
护理部
作者
Kosuke Watabe,Ayumi Goda,Kazuki Tobita,Sachi Yokoyama,Hanako Kikuchi,Kaori Takeuchi,Takumi Inami,Kyoko Soejima,Takashi Kohno
标识
DOI:10.1016/j.healun.2024.04.001
摘要
Abstract
Background
Impaired quality of life (QoL) is prevalent among patients with chronic thromboembolic pulmonary hypertension (CTEPH) despite improved survival due to medical advances. We clarified the physical QoL of patients with CTEPH with mildly elevated pulmonary hemodynamics and evaluated its determinants using a database of patients with CTEPH evaluated for hemodynamics during exercise. Methods
The QoL was measured in 144 patients with CTEPH (age, 66 (58-73) years; men/women, 48/96) with mildly elevated mean pulmonary artery pressure (< 30 mmHg) at rest after treatment with balloon pulmonary angioplasty and/or pulmonary endarterectomy using the Short-Form 36 (SF-36) questionnaire. The enrolled patients were divided into two groups: physical component summary (PCS) scores in the SF-36 over 50 as PCS-good and those under 50 as PCS-poor. Results
The median PCS in SF-36 score was 43.4 (IQR 32.4-49.5) points. The PCS-poor group (n = 110) was older and had lower exercise capacity and SaO2 during exercise. PCS scores were correlated with 6-minute walk distance (rs = 0.40, p < 0.001), quadriceps strength (rs = 0.34, p < 0.001), peak VO2 (rs = 0.31, p < 0.001), SaO2 at rest (rs = 0.35, p < 0.001) and peak exercise (rs = 0.33, p < 0.001), home oxygen therapy usage (rs = −0.28, p=0.001), and pulmonary vascular resistance at peak exercise (rs = −0.26, p=0.002). Conclusions
The impairment of physical QoL was common in patients with CTEPH with improved hemodynamics; exercise capacity, hypoxemia, and hemodynamic status during exercise were related to the physical QoL.
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