Simultaneously Enhancing NIR‐II Emission, Type‐I, and Type‐II Photosensitization Through Acceleration of Charge‐Separated‐State Formation for Tumor Phototheranostics

generation efficiencies of 6TP-IH are improved to 15.6, 2.21, and 3.38 times to those of 8TP-IF. Encapsulation of 6TP-IH into nanoparticles (NPs) enables their application in NIR-II fluorescence image-guided tumor combination therapy. Both in vitro and in vivo studies confirm the precise tumor imaging capability of 6TP-IH NPs, along with robust tumor ablation and effective activation of tumor immunogenic cell death (ICD) through synergistic photodynamic and photothermal therapy. These effects collectively yield an impressive tumor inhibition rate of 99.1% in a 4T1 tumor-bearing mouse model.