CD36
清道夫受体
脂质代谢
下调和上调
血管平滑肌
生物
基因敲除
细胞生物学
脂滴
受体
泡沫电池
生物化学
内分泌学
胆固醇
细胞凋亡
脂蛋白
平滑肌
基因
作者
Tingting Li,Zhi‐Han Tang,Tao-Hua Li,Xiang Qiu,Yanyu Chen,Xi-Long Zheng,Juan Peng,Zhi‐Han Tang
标识
DOI:10.1016/j.yexcr.2023.113666
摘要
TM6SF2, predominantly expressed in the liver and intestine, is closely associated with lipid metabolism. We have demonstrated the presence of TM6SF2 in VSMCs within human atherosclerotic plaques. Subsequent functional studies were conducted to investigate its role in lipid uptake and accumulation in human vascular smooth muscle cells (HAVSMCs) using siRNA knockdown and overexpression techniques. Our results showed that TM6SF2 reduced lipid accumulation in oxLDL-stimulated VSMCs, likely through the regulation of lectin-like oxLDL receptor 1 (LOX-1) and scavenger receptor cluster of differentiation 36 (CD36) expression. We concluded that TM6SF2 plays a role in HAVSMC lipid metabolism with opposing effects on cellular lipid droplet content by downregulation of LOX-1 and CD36 expression.
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