A Metal‐free and Operationally Simple Radical Trifluoromethylative Borylation of Unactivated Alkenes

We herein describe a protocol to synthesize trifluoromethyl boronates from alkenes by the mutual activation of the Togni II reagent and the bis(catecholato)diboron reagent in the absence of any catalyst and additives. This reaction enables synthesizing a series of trifluoromethyl alkyl boronates using unactivated alkenes, including natural products and drug derivatives, in a regioselective manner. Moreover, the synthetic utility of the boronic ester present in the product allows access to a range of trifluoromethyl containing compounds. The radical trapping and gas detection experiments reveal that the more Lewis acidic diboron reagent determines the rapid formation of trifluoromethyl and boron centered radicals.