活性氧
铱
血小板活化
血小板
共轭体系
苯硼酸
部分
吡那考
化学
光化学
生物物理学
生物化学
催化作用
生物
立体化学
免疫学
有机化学
聚合物
作者
Hey Young Yoon,Yecheol Bak,Seung Bin Park,Subba Rao Cheekatla,Kyung Ho Shin,Sehoon Kim,Jung Hoon Lee
标识
DOI:10.1002/admi.202202408
摘要
Abstract In diabetes, platelets are activated by several stimuli, and the activated platelets generate reactive oxygen species (ROS) to induce the aggregation of platelets followed by thrombus formation resulting in various cardiovascular diseases. Therefore, detecting ROS perturbations in platelets can provide a clue to diagnosing diabetes. In this paper, iridium‐based self‐immolative probes ( 1a‐1c ) are reported to monitor perturbations of ROS in the blood through photoluminescence (PL) and electrochemiluminescence (ECL). The probes are designed based on an iridium complex conjugated with phenylboronic acid pinacol ester through carbamate moiety. Three probes contain distinct electron‐withdrawing groups at the ortho‐position in the benzyl linker; thus, subtle reactivity differences are expected against ROS. As expected, all three probes exhibit the most apparent PL changes against hydrogen peroxide (H 2 O 2 ), but their response patterns against ROS are interestingly distinctive. Utilizing such differential ROS responsive pattern, a discrimination strategy is established using a combination of PL and ECL responses, and discrimination of platelets from diabetic and control rats is successfully demonstrated.
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