细菌外膜
生物发生
肽聚糖
单元格信封
外膜外排蛋白
膜
外层空间
细胞壁
细胞生物学
革兰氏阴性菌
内膜
生物
外膜转位酶
生物物理学
化学
膜蛋白
生物化学
整体膜蛋白
线粒体膜转运蛋白
计算机科学
大肠杆菌
空格(标点符号)
操作系统
基因
作者
Randi L. Guest,Thomas J. Silhavy
标识
DOI:10.1016/j.bbamcr.2022.119405
摘要
The outer membrane is a distinguishing feature of the Gram-negative envelope. It lies on the external face of the peptidoglycan sacculus and forms a robust permeability barrier that protects extracytoplasmic structures from environmental insults. Overcoming the barrier imposed by the outer membrane presents a significant hurdle towards developing novel antibiotics that are effective against Gram-negative bacteria. As the outer membrane is an essential component of the cell, proteins involved in its biogenesis are themselves promising antibiotic targets. Here, we summarize key findings that have built our understanding of the outer membrane. Foundational studies describing the discovery and composition of the outer membrane as well as the pathways involved in its construction are discussed.
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