自愈水凝胶
再生(生物学)
3D生物打印
纳米技术
材料科学
生物医学工程
细胞生物学
组织工程
工程类
生物
高分子化学
作者
Long Bai,Mengmeng Li,Jiacan Su
出处
期刊:International Journal of bioprinting
[Whioce Publishing Pte Ltd.]
日期:2023-02-17
卷期号:9 (2): 688-688
被引量:1
摘要
Light-based three-dimensional (3D) printing of hydrogels has been widely adopted for accelerating bone regeneration. However, the design principles of traditional hydrogels do not take into consideration the biomimetic regulation of multiple stages throughout the bone healing, and the hydrogels made cannot effectively induce sufficient osteogenesis, which in turn greatly limits their capacity in guiding bone regeneration. The recent progress achieved in DNA hydrogel, which is based on synthetic biology, could facilitate the innovation of the current strategy due to its advantages, such as resistance to enzymatic degradation, programmability, structural controllability, and mechanical properties. However, 3D printing of DNA hydrogel is not well defined and appears to have a few distinct early forms. In this article, a perspective on the early development of 3D printing of DNA hydrogels is presented, and a potential implication of the hydrogel-based bone organoids builtup for bone regeneration is proposed.
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