前药
骨肉瘤
两亲性
纳米技术
姜黄素
材料科学
癌症研究
化学
生物化学
医学
共聚物
复合材料
聚合物
作者
Dong Xu,Yuxin Wan,Zhenze Xie,Chang Du,Yingjun Wang
标识
DOI:10.1002/adhm.202202668
摘要
Abstract Efficient delivery of cargo into target cells is a formidable challenge in modern medicine. Despite the great promise of biomimetic hydroxyapatite (HA) particles in tissue engineering, their potential applications in bone tumor therapy, particularly their structure–function relationships in cargo delivery to target cells, have not yet been well explored. In this study, biomimetic multifunctional composite microparticles (Bm‐cMPs) are developed by integrating an amphiphilic prodrug of curcumin with hierarchically structured HA microspheres (Hs‐hMPs). Then, the effects of the hierarchical structure of vehicles on the integration and delivery of cargo as well as the anti‐osteosarcoma (OS) effect of the composite are determined. Different hierarchical structures of the vehicles strongly influence the self‐assembly behavior of the prodrug. The flake‐like crystals of Hs‐hMPs enable the highest loading capacity and enhance the stability of the cargo. Compared to the normal cells, OS cells exhibit 3.56‐times better uptake of flake‐like Hs‐hMPs, facilitating the selective anti‐tumor effect of the prodrug. Moreover, Bm‐cMPs suppress tumor growth and metastasis by promoting apoptosis and inhibiting cell proliferation and tumor vascularization. The findings shed light on the potential application of Bm‐cMPs and suggest a feasible strategy for developing an effective targeted therapy platform using hierarchically structured minerals for OS treatment.
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