Luffa acutangula (L. acutangula), commonly known as sponge gourd or ridge gourd, is a perennial plant found in various regions worldwide and has importance in traditional Indian medicine because of its wide-ranging pharmacological properties. This review examines the phytochemical composition of L. acutangula and its therapeutic potential. Phytochemical analysis has identified numerous bioactive compounds, including terpenoids, phenolic acids, flavonoids, and alkaloids, responsible for its diverse pharmacological activities. The review offers a comprehensive overview of L. acutangula, detailing its phytochemistry and pharmacological effects, which enhance our understanding of its therapeutic applications and inspire further research in natural medicine. However, additional research is required to elucidate the mechanisms involved, refine dosage schedules, and explore potential synergistic interactions with standard treatments. The findings presented here underscore the phytoconstituent and therapeutic potential of this plant, highlighting the need for ongoing research and development in the field of natural medicine.