Recent Advances in Metal–Organic Frameworks as Oxidase Mimics: A Comprehensive Review on Rational Design and Modification for Enhanced Sensing Applications

Metal–organic frameworks (MOFs) have emerged as innovative nanozyme mimics, particularly in the area of oxidase catalysis, outperforming traditional MOF-based peroxidase and other nanomaterial-based oxidase systems. This review explores the various advantages that MOFs offer in terms of catalytic activity, low-cost, stability, and structural versatility. With a primary focus on their application in biochemical sensing, MOF-based oxidases have demonstrated remarkable utility, prompting a thorough exploration of their design and modification strategies. Moreover, the review aims to provide a comprehensive analysis of the strategies employed in the rational design and modification of MOF structures to optimize key parameters such as sensitivity, selectivity, and stability in the context of biochemical sensors. Through an exhaustive examination of recent research and developments, this article seeks to offer insights into the nuanced interplay between MOF structures and their catalytic performance, shedding light on the mechanisms that underpin their effectiveness as nanozyme mimics. Finally, this review addresses challenges and opportunities associated with MOF-based oxidase mimics, aiming to drive further advancements in MOF structure design and the development of highly effective biochemical sensors for diverse applications.