Analysis of risk factors affecting prognosis of invasive fungal infection

Objective To explore the risk factors affecting prognosis of invasive fungal infection. Methods The clinical data of 208 hospitalized patients diagnosed with invasive fungal infection in Sun Yat-sen memorial hospital from 2007 to 2011 were reviewed. The factors affecting prognosis were determined by univariate and logistic regression analysis. Results The fatality rate of adult inpatient with invasive fungal infection was 21%. The univariate analysis showed that difference of seven indicators was significant between the survive group and death group： advanced age （over 60 years old）, hospitalization time,fasting plasma glucose level, hypoalbumin- emia, using more than two kinds of broad spectrum antibiotic for more than two weeks, kinds of invasive operations, and multiple organ dysfunction syndrome （MODS）. Binary logistic regression showed that the difference of five indicators was significant between the two groups： advanced age （over 60 years old）, hypoalbnm~nemia, using more than two kinds of broad spectrum antibiotic for more than two weeks, kinds of invasive operations, and multiple organ dysfunction syndrome. Conclusions The indicators such as advanced age （ over 60 years old）, hypoalbuminemia, the use of more than two kinds of broad spectrum antibiotic for more than two weeks, kinds of invasive operations, and multiple organ dysfunction syndrome might be independent risk factors of death in patients with invasive fungal infection. Early medical intervention should be made in clinical work, in order to reduce fatality rate of patients with invasive fungal infection. Key words: Mycoses ;  Risk factors ;  Prognosis ;  Retrospective studies ;  Logistic models