脂联素
生长素
瘦素
内科学
认知功能衰退
医学
认知
人口
队列
内分泌学
肥胖
老年学
激素
疾病
精神科
胰岛素抵抗
痴呆
环境卫生
作者
M Andĕl,Natasja M. van Schoor,Nicole Korten,Hannie C. Comijs,Annemieke C. Heijboer,Madeleine L. Drent
出处
期刊:The Journals of Gerontology
[Oxford University Press]
日期:2020-05-24
卷期号:76 (1): 131-140
被引量:10
标识
DOI:10.1093/gerona/glaa126
摘要
Abstract Background Age-related cognitive decline has large-scale functional and economic consequences and understanding its’ pathophysiological mechanisms is therefore essential. Previous research has suggested associations between hormones adiponectin, ghrelin and leptin and neurodegenerative disease. However, their association with age-related cognitive decline has not been fully described. We examine the association between serum high-molecular-weight (HMW) adiponectin, ghrelin and leptin and age-related cognitive decline in older adults. Methods The associations between HMW adiponectin, ghrelin and leptin and the Mini-Mental-State-Examination, Coding task (Coding), 15 Words Test (15WT) and composite Z-score (general cognitive function) were analyzed by means of a sex-stratified multivariable linear regression analysis in a population-based cohort of 898 older adults at baseline and after 3 years of follow-up. Results In women, we found a positive association between HMW adiponectin and general cognitive function at baseline (fully adjusted model composite Z-score standardized regression co-efficient beta [β] = .089, p = .025). After 3 years of follow-up, HMW adiponectin was associated with more decline in general cognitive function and information processing speed (fully adjusted model composite Z-score β = −.123, p = .018; Coding β = −.116, p = .027). Ghrelin and leptin were significantly associated with memory in a baseline subgroup analysis of older women. For men, we found no significant associations at baseline or follow-up. Conclusion Our results show variable associations between hormones HMW adiponectin, ghrelin and leptin and age-related cognitive decline in women but not in men. As there was no clear trend, all our results should be interpreted with caution.
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