肠道微生物群
微生物群
计算生物学
功能(生物学)
生物
进化生物学
生物信息学
作者
Diling Chen,Longkai Qi,Yuna Guo,Yadi Liu,Xiaocui Tang,Xiangxiang Zhu,Miao Zhang,Li Ran,Ou Shuai,Dongdong Wang,Yizhen Xie,Xiaohong Yuan,Burton B. Yang,Qingping Wu
出处
期刊:Aging
[Impact Journals, LLC]
日期:2020-01-06
卷期号:12 (1): 260-287
被引量:19
标识
DOI:10.18632/aging.102614
摘要
Our pre-experiments found that the brain circRNA sequence profiles and gut microbiota in AD-like mice were changed, as circNF1-419 could enhance autophagy to ameliorate senile dementia in AD-like mice, so we conclude that there might some connections between circRNA and gut microbiome. Therefore, we use the over-expressed circNF1-419 adeno-associated virus (AAV) animal system with the aim of identifying possible connections. Our results showed that over-expression of circNF1-419 in brain not only influenced the cholinergic system of brain, but also changed the gut microbiota composition as the Candidatus Arthromitus, Lachnospiraceae FCS020 group, Lachnospiraceae UCG-006, and [Eubacterium] xylanophilum group, and the intestinal homeostasis and physiology, and even the gut microbiota trajectory in new born mice. These findings demonstrate a link between circRNA and gut microbiome, enlarge the 'microbiome- transcriptome' linkage library and provide more information on gut-brain axis.
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