医学
免疫学
类风湿性关节炎
发病机制
炎症
先天免疫系统
获得性免疫系统
免疫系统
作者
Junhui Bai,Yukun Li,Meixiang Li,Sisi Tan,Daichao Wu
出处
期刊:Current Drug Targets
[Bentham Science]
日期:2020-07-28
卷期号:21 (9): 855-863
被引量:20
标识
DOI:10.2174/1389450121666200429114926
摘要
Interleukin-37 (IL-37) was discovered as a new member of pro-inflammatory IL-1 superfamily. However, further studies suggested that IL-37 plays a critical anti-inflammatory role in innate and adaptive immunity. IL-37 may suppress the inflammatory process via intracellular SMAD family member 3 (SMAD3) and extracellular IL-18 Receptor alpha (IL-18Rα) signaling pathway, respectively. Meanwhile, the abnormal expression of IL-37 was observed in immune-mediated inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, atherosclerosis, systemic lupus erythematosus, asthma, and multiple sclerosis, which suggest IL-37 is a potential therapeutic target for these diseases. In this review, we summarize the anti-inflammatory mechanism of IL-37 and discuss the critical roles of IL-37 in the pathogenesis of these diseases. Further studies are required to confirm the effectiveness of IL-37 as a novel target for these inflammatory diseases.
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