Synthesis of p-tert-butylbenzoic acid by oxidizing with nitric acid

In this article,the synthesis of p-tert-butylbenzoic acid by using nitric acid as the oxidizing agent was introduced.The raw material was p-tert-butyltoluene.Three kinds of conditions which affected the reaction were discussed:The concentration of nitric acid,the temperature and time of the reaction.The best condition was also found by way of orthogonal experimental design.This simple synthetic route was appropriate for industrial production.