Application of Serum Hepatic Fibrosis Indices in the Diagnosis of Hepatic Disease

To investigate the significance of combined detection of laminin(LN),collagen type Ⅳ(CIV),hyaluronic acid(HA) and precollagen type Ⅲ(PCⅢ) in the diagnosis of hepatic fibrosis.The serum levels of LN,CIV,HA and PCⅢ in 143 patients with hepatic disease and 41 healthy controls were measured by radioimmunoassay(RIA).The results showed that the serum levels of LN,CIV,HA and PCⅢ in patients with hepatic disease were significantly higher than those of the control group(P0.01),and the serum levels of those markers were related to the severity of the chronic hepatic disease.The highest serum levels were found in serious chronic hepatitis group and hepatic fibrosis group,and the increase of serum HA and PCⅢ was most remarkable.Combined detection of LN,CIV,HA and PCⅢ is a sensitive and reliable method in the diagnosis of hepatic fibrosis,but the four serum indices can not be used in differentiating serious chronic hepatitis and hepatic fibrosis.