生物
膀胱癌
癌症研究
转移
长非编码RNA
肿瘤进展
车站3
抑制器
结直肠癌
癌症
细胞生长
核糖核酸
信号转导
基因
细胞生物学
遗传学
作者
Qian-Yun Ma,Shuying Li,Xi-Zhou Li,Tengfei Zhou,Yongfu Zhao,Fang-Lin Liu,Xiaona Yu,Jian Lin,Fan-Yue Chen,Jie Cao,Huijun Xi,Hengyu Li
出处
期刊:Gene
[Elsevier]
日期:2019-08-01
卷期号:710: 193-201
被引量:10
标识
DOI:10.1016/j.gene.2019.06.009
摘要
Accumulative researches have demonstrated the critical functions of long non-coding RNAs (lncRNAs) in the progression of malignant tumors, including bladder cancer (BC). Our previous studies showed that lnc-DILC was an important tumor suppressor gene in both liver cancer and colorectal cancer. However, the role of lnc-DILC in BC remains to be elucidated. In the present study, we for first found that lnc-DILC was downregulated in human bladder cancer tissues. Lnc-DILC overexpression suppressed the proliferation, metastasis and expansion of bladder cancer stem cells (CSCs). Mechanically, lnc-DILC suppressed BC cells progression via STAT3 pathway. Special STAT3 inhibitor S3I-201 diminished the discrepancy of growth, metastasis and self-renewal ability between lnc-DILC-overexpression BC cells and their control cells, which further confirmed that STAT3 was acquired for lnc-DILC-disrupted BC cell growth, metastasis and self-renewal. Taken together, our results suggest that lnc-DILC is a novel bladder tumor suppressor and indicate that lnc-DILC inhibits BC progression via inactivating STAT3 signaling.
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