促红细胞生成素肝细胞(Eph)受体
以法林
EPH受体A2
分子生物学
生物
受体
细胞生物学
受体酪氨酸激酶
信号转导
生物化学
作者
Hans Christian Aasheim,Else Munthe,Steinar Funderud,Erlend B. Smeland,Klaus Beiske,Ton Logtenberg
出处
期刊:Blood
[American Society of Hematology]
日期:2000-01-01
卷期号:95 (1): 221-230
被引量:71
标识
DOI:10.1182/blood.v95.1.221
摘要
Abstract Ephrin-A4 is a ligand for the erythropoietin-producing hepatocellular (Eph) receptor family of tyrosine kinases. We have identified a secreted form of ephrin-A4, denoted ephrin-A4 (s), which is encoded by an alternatively spliced mRNA and is produced by in vivo activated B cells in tonsils. Blood B cells secrete ephrin-A4 (s) upon stimulation via the B-cell antigen receptor. A subpopulation of tonsil cells in the crypts with a dendritic cell phenotype was shown to express EphA2, an Eph receptor tyrosine kinase that was found to be capable of binding an ephrin-A4 immunoglobulin chimeric protein. We conclude that ephrin-A4 (s) may play a role in the interaction between activated B lymphocytes and dendritic cells in human tonsils. (Blood. 2000;95:221-230)
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