Delivery of Temporin-FL via Mesoporous Polydopamine Nanoparticles Enhances Antimicrobial Penetration and Accelerates Healing in Staphylococcus aureus -Infected Wounds

experiments using murine full-thickness wound models showed superior skin penetration and accelerated healing. Importantly, histological analysis highlighted robust granulation tissue formation and collagen deposition in the MPDA@Temporin-FL group, concomitantly with reduced pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β). Collectively, these results underscore the dual functionality of MPDA@Temporin-FL: targeted antimicrobial delivery and tissue regenerative modulation. Therefore, this nanoplatform represents a clinically translatable strategy to combat antibiotic-resistant infections while promoting wound repair, addressing critical gaps in current AMP-based therapies.